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Watch videos related to the science of sleep, wakefulness, and narcolepsy, and hear from clinicians.


Exploring histamine in sleep and wakefulness video thumbnail 4 3 1 LL Video Sleep Wake Video Thumbnail M
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Exploring histamine in sleep and wakefulness

Watch a more in-depth discussion about histamine, including key data from animal studies that support the importance of histamine in disorders characterized by sleep-wake state instability, such as narcolepsy.1,2


Pathophysiology of narcolepsy video thumbnail 4 3 1 LL Video Pathophysiology Video Thumbnail M
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The pathophysiology of narcolepsy

Learn more about the neuronal processes involved in the sleep-wake state instability resulting from orexin (hyporectin) loss in narcolepsy.3,4


Recognizing the prevalence and impact of narcolepsy video thumbnail 4 3 Recognizing the prevalence Video Thumbnail M
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Recognizing the prevalence and impact of narcolepsy

Hear Matthew Davis, MD, and Monique Mulvany, NP, discuss narcolepsy and how comorbidities can introduce complexity when diagnosing this disorder.


The role of orexin in sleep-wake instability video thumbnail 4 3 The role of orexin Video Thumbnail M
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The role of orexin in sleep-wake instability

Hear Monique Mulvany, NP, discuss the role of orexin (hypocretin) in relation to sleep and wakefulness.


Interpreting hypnograms in patients with narcolepsy video thumbnail 4.3 Interpreting hypnograms in patients M
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Interpreting hypnograms in patients with narcolepsy

Listen as Monique Mulvany, NP, compares a normal hypnogram to a hypnogram of a patient with narcolepsy.


Narcolepsy diagnostic criteria video thumbnail 4 3 Narcolepsy diagnostic criteria Video Thumbnail M
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Narcolepsy diagnostic criteria

Hear Matthew Davis, MD, present an overview of diagnostic criteria for type 1 and type 2 narcolepsy.


Assessing for EDS and cataplexy video thumbnail 4 3 Assessing for EDS and cataplexy Video Thumbnail M
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Assessing for EDS and cataplexy

Listen as Matthew Davis, MD, discusses the clinical assessment of narcolepsy symptoms in both adult and pediatric patient populations.

EDS, excessive daytime sleepiness.

References

  1. Espana RA, Scammell TE. Sleep neurobiology from a clinical perspective. Sleep. 2011;34(7):845-858
  2. Haas HL, Sergeeva OA, Selbach O. Histamine in the nervous system. Physiol Rev. 2008;88(3):1183-1241.
  3. American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed, text revision. American Academy of Sleep Medicine; 2023.
  4. Scammell TE. Narcolepsy. N Engl J Med. 2015;373(27):2654-2662.

Publications

Stay up to date on scientific research by viewing recent publications about sleep, wakefulness, and narcolepsy.

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Presentations

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