Functional Outcomes of Sleep Questionnaire, Short Form (FOSQ-10)
Functional Outcomes of Sleep Questionnaire, Short Form (FOSQ-10)
The Functional Outcomes of Sleep Questionnaire (FOSQ) is the gold-standard assessment of the impact of sleepiness on daily activities, functional status, and quality of life.1,2 The 30-item FOSQ (FOSQ-30) has proven validity and reliability in clinical trials—including for the assessment of changes with treatment—but may be too long to regularly implement in real-world settings.1
The shortened 10-item, self-administered FOSQ (FOSQ-10) addresses this limitation while retaining similar psychometric properties to the FOSQ-30. The 10 items assess the degree to which sleepiness makes daily functioning difficult across 5 different domains1:
- General productivity
- Activity level
- Vigilance
- Social outcomes
- Intimacy and sexual relationships
Total FOSQ-10 score ranges from 5 to 20, with lower scores indicating greater impairment.1,2
Narcolepsy-specific data
A review of clinical studies in patients with narcolepsy using the FOSQ-10 reported baseline total scores ranging from 11.4 to 12.2. Studies have also indicated that patients with narcolepsy experience the greatest impairment in the domains of activity levels and vigilance.3
Related to assessing improvements in FOSQ-10 score with treatment in patients with narcolepsy, the minimally important difference (smallest change the patient is able to identify) has been estimated to be 1.7, and the clinically important response (change representing a relevant treatment benefit) has been estimated to be 2.5.4
References
- Chasens ER, Ratcliffe SJ, Weaver TE. Development of the FOSQ-10: a short version of the Functional Outcomes of Sleep Questionnaire. Sleep. 2009;32(7):915-919.
- Weaver TE, Laizner AM, Evans LK, et al. An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep. 1997;20(10):835-843.
- Tadrous R, O’Rourke D, Mockler D, Broderick J. Health-related quality of life in narcolepsy: a systematic review and meta-analysis. J Sleep Res. 2021;30(6):e13383. doi:10.1111/jsr.13383
- Weaver TE, Menno DM, Bron M, Crosby RD, Morris S, Mathias SD. Determination of thresholds for minimally important difference and clinically important response on the functional outcomes of sleep questionnaire short version in adults with narcolepsy or obstructive sleep apnea. Sleep Breath. 2021;25(3):1707-1715.
